Retatrutide
Metabolic peptide reducing appetite and enhancing fat burning. One of the most active in its category.
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Compound
Retatrutide
Form
Lyophilized Powder
Purity
>99%
Storage
-20°C
Science
Mechanism of Action
Retatrutide is a first-in-class triple hormonal agonist that simultaneously activates GLP-1, GIP, and glucagon receptors. This triple agonism produces synergistic effects on weight loss, glucose homeostasis, and hepatic lipid metabolism — surpassing the efficacy of single or dual receptor agonists.
Benefits
Research Benefits
- Up to 24.2% body weight reduction in 48-week Phase 2 trials
- Significant reduction in liver fat content (hepatic steatosis)
- Improved insulin sensitivity and glucose tolerance
- Enhanced energy expenditure via glucagon receptor activation
- Cardiovascular benefit markers improved in clinical studies
Research
Dosage Protocol
Research protocols typically follow a titration schedule: 1mg weekly for 4 weeks, escalating to 2mg, 4mg, 6mg, 8mg, and up to 12mg weekly. Subcutaneous administration in animal/in-vitro models.
Technical Specifications
Research Comparison
Compare Specs Side-by-Side
| Peptide | ||
|---|---|---|
| Aliases | LY3437943 | |
| CAS Number | 2381612-46-6 | |
| Molecular Weight | ~4736 g/mol | |
| Sequence | Synthetic peptide (39 amino acids) | |
| Purity | >99% (HPLC) | |
| Form | Lyophilized Powder | |
| Storage | -20°C | |
| Price | £42 | |
| Mechanism | Retatrutide is a first-in-class triple hormonal agonist that simultaneously activates GLP-1, GIP, and glucagon receptors. This triple agonism produces synergistic effects on weight loss, glucose homeostasis, and hepatic lipid metabolism — surpassing the efficacy of single or dual receptor agonists. | |
| Dosage Protocol | Research protocols typically follow a titration schedule: 1mg weekly for 4 weeks, escalating to 2mg, 4mg, 6mg, 8mg, and up to 12mg weekly. Subcutaneous administration in animal/in-vitro models. |
Comparison for research purposes only · All peptides >99% HPLC-verified purity
Stability
Storage Guidelines
Store lyophilized powder at -20°C. After reconstitution with bacteriostatic water, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles.
Safety
Safety & Effects
In clinical trials, the most commonly reported effects included gastrointestinal symptoms (nausea, diarrhea, vomiting), decreased appetite, and injection site reactions. These were generally dose-dependent and mild to moderate in severity.
Scientific Literature
Published Research
New England Journal of Medicine, 2023
Retatrutide for Obesity — Phase 2 Trial
24.2% mean body weight reduction at 48 weeks
PubMed →Nature Medicine, 2023
Triple Hormone Receptor Agonist Retatrutide
Superior weight loss vs semaglutide in preclinical models
PubMed →The Lancet, 2024
Retatrutide and Hepatic Steatosis
Significant reduction in liver fat content observed
PubMed →Research Tool
Peptide Reconstitution Calculator
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Visual Reconstitution Calculator
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Units to Draw
20 U
Volume
0.200 ml
Concentration
50 mcg/U
Total Doses
10
Research use only · Not for human consumption
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