MOTS-C
Peptide improving glucose utilization and fat burning. Combined with physical activity.
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Compound
MOTS-C
Form
Lyophilized Powder
Purity
>99%
Storage
-20°C
Science
Mechanism of Action
MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded by the mitochondrial 16S rRNA gene. It targets the folate-purine-AMPK pathway, improving metabolic homeostasis, insulin sensitivity, and exercise capacity. Unlike most peptides encoded in nuclear DNA, MOTS-c is encoded in mitochondrial DNA — making it a key regulator of mitochondrial-nuclear communication.
Benefits
Research Benefits
- Improves insulin sensitivity and glucose regulation
- Enhances exercise capacity and metabolic flexibility
- Activates AMPK (cellular energy sensor)
- Potential obesity and type 2 diabetes research applications
- Promotes mitochondrial biogenesis and function
- May improve longevity through metabolic optimization
Research
Dosage Protocol
Research protocols typically use 5-10mg administered subcutaneously, 1-3 times weekly. Often studied in metabolic and exercise physiology models. Cycles of 4-8 weeks.
Technical Specifications
Research Comparison
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| Peptide | ||
|---|---|---|
| Aliases | Mitochondrial-Derived Peptide | |
| CAS Number | 1627580-17-7 | |
| Molecular Weight | 2355.75 g/mol | |
| Sequence | MRWQEMGYIFYPRKFR | |
| Purity | >99% (HPLC) | |
| Form | Lyophilized Powder | |
| Storage | -20°C | |
| Price | £27 | |
| Mechanism | MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded by the mitochondrial 16S rRNA gene. It targets the folate-purine-AMPK pathway, improving metabolic homeostasis, insulin sensitivity, and exercise capacity. Unlike most peptides encoded in nuclear DNA, MOTS-c is encoded in mitochondrial DNA — making it a key regulator of mitochondrial-nuclear communication. | |
| Dosage Protocol | Research protocols typically use 5-10mg administered subcutaneously, 1-3 times weekly. Often studied in metabolic and exercise physiology models. Cycles of 4-8 weeks. |
Comparison for research purposes only · All peptides >99% HPLC-verified purity
Stability
Storage Guidelines
Store lyophilized powder at -20°C. Reconstituted solution stable at 2-8°C for up to 30 days. Protect from light and avoid freeze-thaw cycles.
Safety
Safety & Effects
MOTS-c has shown favorable safety in preclinical studies. No significant adverse effects documented at research doses. Mild injection site reactions possible.
Scientific Literature
Published Research
Cell Metabolism, 2015
MOTS-c Mitochondrial Peptide Discovery
Regulates metabolic homeostasis and insulin sensitivity
PubMed →Nature Communications, 2019
MOTS-c and Exercise Capacity
Enhances physical performance and metabolic flexibility
PubMed →Trends in Endocrinology & Metabolism, 2017
MOTS-c in Obesity and Diabetes
Potential therapeutic for metabolic syndrome
PubMed →Research Tool
Peptide Reconstitution Calculator
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Visual Reconstitution Calculator
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Units to Draw
20 U
Volume
0.200 ml
Concentration
50 mcg/U
Total Doses
10
Research use only · Not for human consumption
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